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Article

Sodium selenite inhibits gamma-secretase activity through activation of ERK.

Neuroscience letters - 25 Jul 2008

Tung Ying-Tsen, Hsu Wen-Ming, Wang Bo-Jeng, Wu Shin-Ying, Yen Chen-Tung, Hu Ming-Kuan, Liao Yung-Feng

Abstract excerpt

Previous studies have demonstrated that the ERK MAPK acts as a negative regulator of gamma-secretase. Here, we demonstrate that the activation of ERK MAPK pathway by sodium selenite can inhibit endogenous gamma-secretase activity. Consistently, the gamma-secretase-mediated production of amyloid-b...

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Source

Identifiers

PMID: 18547722
DOI: 10.1016/j.neulet.2008.05.048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18547722-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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