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Article

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

Nature cell biology - 1 Jul 2000

Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L, De Strooper B

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Share to Amyloid beta-Protein Precursor
Share to Amyloid Precursor Protein Secretases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10878813
DOI: 10.1038/35017105

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Related research

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Research trail→

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.PMID 10878813Read ↗

gamma-secretases: from cell biology to therapeutic strategies.Semantic proximity Read ↗

Divergent consequences of PSEN1 knockout and PSEN2 knockout in stem cell derived models of the brainSemantic proximity Read ↗

Function and Dysfunction of PresenilinSemantic proximity Read ↗

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.Semantic proximity Read ↗

More Insights on the Use of γ-Secretase Inhibitors in Cancer Treatment.Semantic proximity Read ↗

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology.Semantic proximity Read ↗

Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cellsSemantic proximity Read ↗

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.Semantic proximity Read ↗

Generation and Characterization of a Novel Knockin Mouse Model Expressing PSEN1 D385A: Implications for Investigating Herbal Drug Effects in γ-Secretase Activity.Semantic proximity Read ↗

Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.Semantic proximity Read ↗

Presenilins and the gamma-secretase: still a complex problem.Semantic proximity Read ↗

A sensitive and quantitative assay for measuring cleavage of presenilin substrates.Semantic proximity Read ↗

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