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4-O-methylhonokiol prevents memory impairment in the Tg2576 transgenic mice model of Alzheimer's disease via regulation of β-secretase activity.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Lee Young-Jung, Choi Dong-Young, Lee Yong Kyoung, Lee Yoot Mo, Han Sang Bae, Kim Young Hee, Kim Ki Ho, Nam Sang-Yoon, Lee Beom Jun, Kang Jong-Koo, Yun Young Won, Oh Ki-Wan, Hong Jin Tae

Abstract excerpt

Alzheimer's disease (AD), the most common form of dementia, is characterized by memory deficits and deposition of amyloid-β (Aβ) in the brain. It has been known that neuroinflammation and oxidative stress are critical factors in the development of AD. 4-O-methylhonokiol, an extract from Magnolia officinalis, is known to have anti-inflammatory and anti-oxidative effects. Thus, we investigated the properties of...

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PMID: 22330831
DOI: 10.3233/JAD-2012-111835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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