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Article

ERK1/2 is an endogenous negative regulator of the gamma-secretase activity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2006

Kim Su-Kyoung, Park Hyun-Jung, Hong Hyun Seok, Baik Eun Joo, Jung Min Whan, Mook-Jung Inhee

Abstract excerpt

As an essential protease in the generation of amyloid beta, gamma-secretase is believed to play an important role in the pathogenesis of Alzheimer's disease. Although a great deal of progress has been made in identifying the components of gamma-secretase complex, the endogenous regulatory mechanism of gamma-secretase is unknown. Here we show that gamma-secretase is endogenously regulated via extracellular signal...

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Source

Identifiers

PMID: 16293708
DOI: 10.1096/fj.05-4055fje

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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