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Article

Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Oct 2007

Li Tong, Wen Hongjin, Brayton Cory, Laird Fiona M, Ma Guojun, Peng Shiwen, Placanica Lisa, Wu T C, Crain Barbara J, Price Donald L, Eberhart Charles G, Wong Philip C

Abstract excerpt

Although gamma-secretase is recognized as a therapeutic target for Alzheimer's disease, side effects associated with strong inhibition of this aspartyl protease raised serious concerns regarding this therapeutic strategy. However, it is not known whether moderate inhibition of this enzyme will allow dissociation of beneficial effects in the CNS from mechanism-based toxicities in the periphery. We tested this...

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Identifiers

PMID: 17913918
DOI: 10.1523/JNEUROSCI.2152-07.2007
PMCID: PMC6672827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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