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Article

Effects of TCF7L2 polymorphisms on obesity in European populations.

Obesity (Silver Spring, Md.) - 1 Feb 2008

Cauchi Stéphane, Choquet Hélène, Gutiérrez-Aguilar Ruth, Capel Frédéric, Grau Katrine, Proença Christine, Dina Christian, Duval Alex, Balkau Beverley, Marre Michel, Potoczna Natascha, Langin Dominique, Horber Fritz, Sørensen Thorkild I A, Charpentier Guillaume, Meyre David, Froguel Philippe

Abstract excerpt

The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele was previously associated with type 2 diabetes (T2D) and decreased BMI whereas haplotypes carrying the rs7903146 C and rs10885406 A alleles (HapA) were associated with increased BMI. The functional relevance of TCF7L2 polymorphisms and their effects on T2D and obesity remained to be further investigated. In white European populations, we found that the...

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Identifiers

PMID: 18239663
DOI: 10.1038/oby.2007.77

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