Article
Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic Risk Scores.
Nutrients - 6 Dec 2016
Corella Dolores, Coltell Oscar, Sorlí Jose V, Estruch Ramón, Quiles Laura, Martínez-González Miguel Ángel, Salas-Salvadó Jordi, Castañer Olga, Arós Fernando, Ortega-Calvo Manuel, Serra-Majem Lluís, Gómez-Gracia Enrique, Portolés Olga, Fiol Miquel, Díez Espino Javier, Basora Josep, Fitó Montserrat, Ros Emilio, Ordovás José M
Abstract excerpt
Nutrigenetic studies analyzing gene-diet interactions of the TCF7L2-rs7903146 C > T polymorphism on type-2 diabetes (T2D) have shown controversial results. A reason contributing to this may be the additional modulation by obesity. Moreover, TCF7L2-rs7903146 is one of the most influential variants in T2D-genetic risk scores (GRS). Therefore, to increase the predictive value (PV) of GRS it is necessary to first see...
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