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Article

Val/Met polymorphism of the COMT gene moderates the association between job strain and early atherosclerosis in young men.

Journal of occupational and environmental medicine - 1 Jun 2008

Hintsanen Mirka, Elovainio Marko, Puttonen Sampsa, Kivimäki Mika, Lehtimäki Terho, Kähönen Mika, Juonala Markus, Rontu Riikka, Viikari Jorma S A, Raitakari Olli T, Keltikangas-Järvinen Liisa

Abstract excerpt

OBJECTIVE: Several studies support job strain as a risk factor for coronary heart disease (CHD) but null findings also exist. Individual differences in innate stress vulnerability might in part explain the mixed findings. COMT gene influences dopamine transmission and dopaminergic activity might moderate effects of stress on CHD risk. We examine whether COMT Val158Met polymorphism moderates the association...

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Source

Identifiers

PMID: 18545092
DOI: 10.1097/JOM.0b013e318165c7ec

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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