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Article

COMT and ACE (Epi)genetic Variation Is Associated with Cognitive and Metabolic Resilience in Swiss Tactical Athletes.

International journal of molecular sciences - 29 Jan 2026

Flück Martin, Protte Christian, Giraud Marie-Noëlle, Häusler Eric, Züger Regula, Dössegger Alain

Abstract excerpt

Resilience to stress integrates cognitive, physiological, and behavioral adaptations to sustain performance under adversity. Genetic variation in catechol-O-methyltransferase (COMT, rs4680) and angiotensin-converting enzyme (ACE, rs1799752) modulates dopaminergic and renin-angiotensin signaling, influencing tissue oxygenation and fatigue resistance. We examined COMT- and ACE-promoter methylation and genotypes in...

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Source

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Identifiers

PMID: 41683763
DOI: 10.3390/ijms27031340
PMCID: PMC12898589

Genes

COMT
ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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