Associations between APOE-, COMT Val108/158Met- and BDNF Val66Met polymorphisms and variations in depressive and anxiety symptoms, sense of coherence and vital exhaustion in the real-life setting of mandatory basic military training.

doi:10.1007/s00702-020-02280-1

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Article

Associations between APOE-, COMT Val108/158Met- and BDNF Val66Met polymorphisms and variations in depressive and anxiety symptoms, sense of coherence and vital exhaustion in the real-life setting of mandatory basic military training.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2021

Alexopoulos Panagiotis, Papanastasiou Anastasios D, Εconomou Polychronis, Beis Pavlos, Niforas Michail, Dassios Theodore G, Kormpaki Aggeliki, Zarkadis Ioannis K, Reichel Martin, Kornhuber Johannes, Perneczky Robert, Gourzis Philippos

Abstract excerpt

Apolipoprotein E (APOE) ε, catechol-O-methytranferase (COMT) Val108/158Met and brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphisms (SNPs) were shown to affect stress perception and response. The present study explored possible associations between these SNPs and changes in subclinical anxiety- and depressive symptoms, sense of coherence (SOC) and vital exhaustion (VE) during...

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PMID: 33394176
DOI: 10.1007/s00702-020-02280-1

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