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Article

Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats.

Psychopharmacology - 1 Oct 2008

Olivier J D A, Jans L A W, Korte-Bouws G A H, Korte S M, Deen P M T, Cools A R, Ellenbroek B A, Blokland A

Abstract excerpt

RATIONALE: Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats. OBJECTIVES: As individual differences exist in central serotonin neurotransmission, the impact of ATD may vary accordingly. In this experiment, we investigated the hypothesis that male serotonin...

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PMID: 18542930
DOI: 10.1007/s00213-008-1201-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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