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Article

Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans.

The pharmacogenomics journal - 1 Dec 2013

Fox M A, Panessiti M G, Moya P R, Tolliver T J, Chen K, Shih J C, Murphy D L

Abstract excerpt

A possible side effect of serotonin-enhancing drugs is the serotonin syndrome, which can be lethal. Here we examined possible hypersensitivity to two such drugs, the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) and the atypical opioid tramadol, in mice lacking the genes for both monoamine oxidase A (MAOA) and MAOB. MAOA/B-knockout (KO) mice displayed baseline serotonin syndrome behaviors, and these...

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Source

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Identifiers

PMID: 22964922
DOI: 10.1038/tpj.2012.35
PMCID: PMC3562558

Genes

MAOA
MAOB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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