Article
Matrix metalloproteinase-3 gene polymorphism and dilatative pathology of ascending thoracic aorta.
Medicina (Kaunas, Lithuania) - 1 Jan 2008
Lesauskaite Vaiva, Sinkūnaite Giedre, Benetis Rimantas, Grabauskas Vilius, Vaskelyte Jolanta, Smalinskiene Alina, Simonyte Sandrita, Jariene Giedre, Tatarūnas Vacis, Klumbiene Jūrate, Petkeviciene Janina, Kinduris Sarūnas, Giedraitis Saulius, Sakalauskas Juozas, Bolys Ramūnas, Sirvinskas Edmundas, Lenkutis Tadas, Pangonyte Dalia
Abstract excerpt
Matrix metalloproteinase-3 (MMP-3) degrades extracellular matrix and may lead to development of dilatative pathology of ascending thoracic aorta. Expression of MMP-3 depends upon the 5A/6A polymorphism in the promoter region. An increased number of 5A alleles leads to high expression of MMP-3. Thus, objective of the study was to determine whether the 5A/6A polymorphism in the promoter region of MMP-3 gene is...
Topics
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Alleles
- Aortic Dissection
- Aorta, Thoracic
- Aortic Aneurysm, Thoracic
- DNA