Article
Flavonoids alter P‐gp expression in intestinal epithelial cells<i>in vitro</i>and<i>in vivo</i>
13 Feb 2007
Abstract excerpt
Flavonoids are secondary plant metabolites included in our diet but are also provided in a growing number of supplements. They are suggested to interact with intestinal transport systems including phospho-glycoprotein (P-gp) which mediates the efflux of a variety of xenobiotics back into the gut lumen. In human intestinal Caco-2 cells, we tested the effects of 14 different flavonoids on P-gp expression in vitro....
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