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Pregnane X receptor-mediated induction of Cyp3a by black cohosh

27 Oct 2010

Abstract excerpt

Black cohosh (BC) has been widely applied for the treatment of menopausal symptoms. However, increasing concerns about herb-drug interactions demand the need for studies on the influence of BC on cytochrome 450. Cyp3a11 in liver was induced by 7-fold in wild-type mice treated with 500 mg/kg black cohosh for 28 days compared with the control group as assessed by quantitative real-time PCR; no difference was found...

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PMID: 20979450
DOI: 10.3109/00498254.2010.527021

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