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Article

Phytochemicals reverse P-glycoprotein mediated multidrug resistance via signal transduction pathways

9 May 2021

Abstract excerpt

P-glycoprotein, encoded by ATP-binding cassette transporters B1 gene (ABCB1), renders multidrug resistance (MDR) during cancer chemotherapy. Several synthetic small molecule inhibitors affect P-glycoprotein (P-gp) transport function in MDR tumor cells. However, inhibition of P-gp transport function adversely accumulates chemotherapeutic drugs in non-target normal tissues. Moreover, most small-molecule P-gp...

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PMID: 34243600
DOI: 10.1016/j.biopha.2021.111632

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