Article
Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin
1 Jan 2001
Abstract excerpt
Intestinal P-glycoprotein, which is encoded by the MDR1 gene, plays an important role in the absorption and presystemic elimination of many xenobiotics. Hence, an understanding of the factors regulating its expression and function is of substantial interest. In addition to genetic factors, exposure to drugs such as rifampin can profoundly affect its expression. So far, the mechanisms by which rifampin induces...
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