Article
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility.
Cell - 14 Nov 1997
Edelmann W, Yang K, Umar A, Heyer J, Lau K, Fan K, Liedtke W, Cohen P E, Kane M F, Lipford J R, Yu N, Crouse G F, Pollard J W, Kunkel T, Lipkin M, Kolodner R, Kucherlapati R
Abstract excerpt
Mice carrying a null mutation in the mismatch repair gene Msh6 were generated by gene targeting. Cells that were homozygous for the mutation did not produce any detectable MSH6 protein, and extracts prepared from these cells were defective for repair of single nucleotide mismatches. Repair of 1, 2, and 4 nucleotide insertion/deletion mismatches was unaffected. Mice that were homozygous for the mutation had a...
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