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Article

Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability.

The Journal of biological chemistry - 29 Mar 1996

Johnson R E, Kovvali G K, Prakash L, Prakash S

Abstract excerpt

Defects in DNA mismatch repair result in instability of simple repetitive DNA sequences and elevated levels of spontaneous mutability. The human G/T mismatch binding protein, GTBP/p160, has been suggested to have a role in the repair of base-base and single nucleotide insertion-deletion mismatches. Here we examine the role of the yeast GTBP homolog, MSH6, in mismatch repair. We show that both MSH6 and MSH3 genes...

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Source

Identifiers

PMID: 8631743
DOI: 10.1074/jbc.271.13.7285

Genes

MSH6
MSH3
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability.PMID 8631743Read ↗

A mutation in the MSH6 subunit of the Saccharomyces cerevisiae MSH2-MSH6 complex disrupts mismatch recognition.Semantic proximity Read ↗

Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern.Semantic proximity Read ↗

Multiple factors insulate Msh2-Msh6 mismatch repair activity from defects in Msh2 domain I.Semantic proximity Read ↗

The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis.Semantic proximity Read ↗

Evidence for Involvement of Yeast Proliferating Cell Nuclear Antigen in DNA Mismatch RepairSemantic proximity Read ↗

Genome-wide contributions of the MutSα- and MutSβ-dependent DNA mismatch repair pathways to the maintenance of genetic stability in Saccharomyces cerevisiae.Semantic proximity Read ↗

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.Semantic proximity Read ↗

Mispair-specific recruitment of the Mlh1-Pms1 complex identifies repair substrates of the Saccharomyces cerevisiae Msh2-Msh3 complex.Semantic proximity Read ↗

Analysis of yeast MSH2-MSH6 suggests that the initiation of mismatch repair can be separated into discrete steps.Semantic proximity Read ↗

HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions.Semantic proximity Read ↗

Saccharomyces cerevisiae Msh2-Msh3 acts in repair of base-base mispairs.Semantic proximity Read ↗

Novel dominant mutations in Saccharomyces cerevisiae MSH6.Semantic proximity Read ↗

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