Article
In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells.
Journal of translational medicine - 15 Sept 2008
Koido Shigeo, Homma Sadamu, Hara Eiichi, Mitsunaga Makoto, Namiki Yoshihisa, Takahara Akitaka, Nagasaki Eijiro, Komita Hideo, Sagawa Yukiko, Ohkusa Toshifumi, Fujise Kiyotaka, Gong Jianlin, Tajiri Hisao
Abstract excerpt
BACKGROUND: Human hepatocellular carcinoma (HCC) cells express WT1 and/or carcinoembryonic antigen (CEA) as potential targets for the induction of antitumor immunity. In this study, generation of cytotoxic T lymphocytes (CTL) and regulatory T cells (Treg) by fusions of dendritic cells (DCs) and HCC cells was examined. METHODS: HCC cells were fused to DCs either from healthy donors or the HCC patient and...
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