Article
Human dendritic cell maturation by adenovirus transduction enhances tumor antigen-specific T-cell responses.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000
Schumacher Lana, Ribas Antoni, Dissette Vivian B, McBride William H, Mukherji Bijay, Economou James S, Butterfield Lisa H
Abstract excerpt
Dendritic cells (DCs) have been shown to require a degree of maturation to stimulate antigen-specific, type 1 cytotoxic T lymphocytes in numerous murine models. Limited data in humans suggest that immature DCs (DC) can induce tolerance, yet a variety of nonmatured DC used clinically have induced...
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