Article
Targeting dendritic cell signaling to regulate the response to immunization.
Blood - 15 Mar 2008
Escors David, Lopes Luciene, Lin Rongtuan, Hiscott John, Akira Shizuo, Davis Roger J, Collins Mary K
Abstract excerpt
Dendritic cells (DCs) are key regulators of the immune system; they capture antigens and then can either stimulate an immune response or induce tolerance. Our aim was to activate individual DC signaling pathways to regulate the immune response. We therefore expressed constitutive activators of mitogen-activated protein kinase (MAPK) pathways or the interferon pathway, together with tumor antigens, using...
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