Characterization of swine susceptible to malignant hyperthermia by in vivo, in vitro and post-mortem techniques.

Abstract excerpt

We investigated German Landrace pigs from a special breeding program producing animals which were of three genotypes with respect to in vivo halothane inhalation (i.e., exposure to 3% halothane for up to 3 min): (1) Hal NN, i.e. homozygous normal exhibiting no response; (2) Hal Nn, i.e. heterozygous, also responding with a normal reaction; and (3) Hal nn, i.e. homozygous for the 'halothane gene n' which exhibited...

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