Article
Characterization of swine susceptible to malignant hyperthermia by in vivo, in vitro and post-mortem techniques.
Acta anaesthesiologica Scandinavica - 1 May 1991
Seewald M J, Eichinger H M, Lehmann-Horn F, Iaizzo P A
Abstract excerpt
We investigated German Landrace pigs from a special breeding program producing animals which were of three genotypes with respect to in vivo halothane inhalation (i.e., exposure to 3% halothane for up to 3 min): (1) Hal NN, i.e. homozygous normal exhibiting no response; (2) Hal Nn, i.e. heterozygous, also responding with a normal reaction; and (3) Hal nn, i.e. homozygous for the 'halothane gene n' which exhibited...
Topics
- Administration, Inhalation
- Animals
- Caffeine
- Creatine Kinase
- Disease Susceptibility
- Genotype
- Halothane
- Heterozygote
- Homozygote
- In Vitro Techniques
- Malignant Hyperthermia