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Article

Cosegregation of porcine malignant hyperthermia and a probable causal mutation in the skeletal muscle ryanodine receptor gene in backcross families.

Genomics - 1 Nov 1991

Otsu K, Khanna V K, Archibald A L, MacLennan D H

Abstract excerpt

A study of the inheritance of malignant hyperthermia (MH) in the British Landrace breed revealed the same substitution of T for C at nucleotide 1843 in the ryanodine receptor (RYR1) gene that was previously shown to be correlated with MG in five Canadian swine breeds. Cosegregation of the mutation with MH in 338 informative meioses led to a lod score of 101.75 for linkage at Omax = 0.0. The substitution was also...

Topics

Animals
Crosses, Genetic
Genetic Markers
Genetic Testing
Heterozygote
Malignant Hyperthermia
Muscle Proteins
Mutation
Pedigree
Receptors, Cholinergic
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ryanodine Receptor Calcium Release Channel

Swine

Swine Diseases

Source

Identifiers

PMID: 1774073
DOI: 10.1016/0888-7543(91)90083-q

Genes

RYR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1774073-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Cosegregation of porcine malignant hyperthermia and a probable causal mutation in the skeletal muscle ryanodine receptor gene in backcross families.PMID 1774073Read ↗

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