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Article

The genetic basis of malignant hyperthermia.

Trends in pharmacological sciences - 1 Aug 1992

MacLennan D H

Abstract excerpt

Anaesthesia can induce skeletal muscle rigidity, hypermetabolism and high fever in humans genetically predisposed to malignant hyperthermia. If not immediately reversed, such episodes can lead to tissue damage and death. In swine with the corresponding condition, stress can induce death or lead t...

Topics

Anesthesia
Animals
Calcium
Calcium Channels
Humans
Malignant Hyperthermia
Muscle Contraction
Mutation
Receptors, Cholinergic
Ryanodine Receptor Calcium Release Channel
Sarcoplasmic Reticulum
Swine
Swine Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1329295
DOI: 10.1016/0165-6147(92)90101-b

Genes

RYR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1329295-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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