The genetic basis of malignant hyperthermia.

Article

The genetic basis of malignant hyperthermia.

Annals of the Academy of Medicine, Singapore - 1 Jul 1994

Moochhala S M, Tan W T, Lee T L

Abstract excerpt

Malignant hyperthermia (MH) susceptibility remains the commonest cause of death owing to general anaesthesia. In humans, genetically predisposed to MH, anaesthesia can induce skeletal muscle rigidity, hypermetabolism and hyperthermia, which if not immediately reversed can lead to tissue injury an...

Topics

Animals
Calcium Channels
Disease Models, Animal
Genetic Linkage
Humans
Malignant Hyperthermia
Muscle Proteins
Mutation
Ryanodine Receptor Calcium Release Channel
Swine

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