Malignant hyperthermia.

doi:10.1126/science.1589759

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Article

Malignant hyperthermia.

Science (New York, N.Y.) - 8 May 1992

MacLennan D H, Phillips M S

Abstract excerpt

In humans genetically predisposed to malignant hyperthermia, anesthesia can induce skeletal muscle rigidity, hypermetabolism, and high fever, which, if not immediately reversed, can lead to tissue damage or death. The corresponding condition in swine leads to stress-induced deaths and devalued me...

Topics

Animals
Calcium
Humans
Malignant Hyperthermia
Models, Biological
Muscles
Mutation
Receptors, Cholinergic
Ryanodine Receptor Calcium Release Channel
Sarcoplasmic Reticulum
Swine
Swine Diseases

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