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Article

A genome-wide analysis of the response to inhaled β2-agonists in chronic obstructive pulmonary disease.

The pharmacogenomics journal - 1 Aug 2016

Hardin M, Cho M H, McDonald M-L, Wan E, Lomas D A, Coxson H O, MacNee W, Vestbo J, Yates J C, Agusti A, Calverley P M A, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Bhatt S P, Kim V, Ramsdell J, Regan E A, Make B J, Hokanson J E, Crapo J D, Beaty T H, Hersh C P

Abstract excerpt

Short-acting β2-agonist bronchodilators are the most common medications used in treating chronic obstructive pulmonary disease (COPD). Genetic variants determining bronchodilator responsiveness (BDR) in COPD have not been identified. We performed a genome-wide association study (GWAS) of BDR in 5789 current or former smokers with COPD in one African-American and four white populations. BDR was defined as the...

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Source

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Identifiers

PMID: 26503814
DOI: 10.1038/tpj.2015.65
PMCID: PMC4848212

Genes

CDH13
KCNJ2
KCNK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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