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Article

Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence.

Biological psychiatry - 1 Dec 2008

Li Ming D, Lou Xiang-Yang, Chen Guobo, Ma Jennie Z, Elston Robert C

Abstract excerpt

BACKGROUND: Epidemiological data indicate that nicotine dependence (ND) are influenced by genes, environmental factors, and their interactions. Although it has been documented from molecular experiments that brain-derived neurotrophic factor (BDNF) exerts its functions via neurotrophic tyrosine kinase receptor 2 (NTRK2) and both alpha 4 (CHRNA4) and beta 2 (CHRNB2) subunits are required to form functional alpha 4...

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Source

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Identifiers

PMID: 18534558
DOI: 10.1016/j.biopsych.2008.04.026
PMCID: PMC2592606

Genes

CHRNA4
CHRNB2
NTRK2
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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