Article
Molecular mechanisms associated with leukemic transformation of MPL-mutant myeloproliferative neoplasms.
Haematologica - 1 Dec 2010
Beer Philip A, Ortmann Christina A, Stegelmann Frank, Guglielmelli Paola, Reilly John T, Larsen Thomas S, Hasselbalch Hans C, Vannucchi Alessandro M, Möller Peter, Döhner Konstanze, Green Anthony R
Abstract excerpt
Somatic activating mutations in MPL, the thrombopoietin receptor, occur in the myeloproliferative neoplasms, although virtually nothing is known about their role in evolution to acute myeloid leukemia. In this study, the MPL T487A mutation, identified in de novo acute myeloid leukemia, was not de...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.