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Article

Genetic basis of variation in tenofovir drug susceptibility in HIV-1.

AIDS (London, England) - 19 Jun 2008

Murray Robert J, Lewis Fraser I, Miller Michael D, Brown Andrew J Leigh

Abstract excerpt

OBJECTIVE: To develop an improved model for the genetic basis of reduced susceptibility to tenofovir in vitro. METHODS: A dataset of 532 HIV-1 subtype B reverse transcriptase genotypes for which matched phenotypic susceptibility data were available was assembled, both as a continuous (transformed) dataset and a categorical dataset generated by imposing a cut-off on the basis of earlier studies of in-vivo response...

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PMID: 18525256
DOI: 10.1097/QAD.0b013e32830184a1

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