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Article

Multiple sites in HIV-1 reverse transcriptase associated with virological response to combination therapy

1 Jan 2000

Abstract excerpt

OBJECTIVE: To determine whether analysis of sequence variation in reverse transcriptase at baseline can explain differences in response to combination antiretroviral therapy. METHODS: Amino acid sequences of reverse transcriptase obtained from baseline isolates from 55 patients included in a trial of zidovudine and didanosine versus zidovudine/didanosine/nevirapine (ACTG241) were analysed. Simple and multiple...

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PMID: 10714565
DOI: 10.1097/00002030-200001070-00004

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