Article
International cohort analysis of the antiviral activities of zidovudine and tenofovir in the presence of the K65R mutation in reverse transcriptase.
Antimicrobial agents and chemotherapy - 1 Apr 2010
Grant Philip M, Taylor Jonathan, Nevins Andrew B, Calvez Vincent, Marcelin Anne-Geneviève, Wirden Marc, Zolopa Andrew R
Abstract excerpt
A K65R mutation in HIV-1 reverse transcriptase can occur with the failure of tenofovir-, didanosine-, abacavir-, and, in some cases, stavudine-containing regimens and leads to reduced phenotypic susceptibility to these drugs and hypersusceptibility to zidovudine, but its clinical impact is poorly described. We identified isolates with the K65R mutation within the Stanford Resistance Database and a French cohort...
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