Article
Transcription factor ATF-3 regulates allele variation phenotypes of the human SLC11A1 gene.
Molecular biology reports - 1 Mar 2013
Taka Styliani, Gazouli Maria, Politis Panagotis K, Pappa Kalliopi I, Anagnou Nicholas P
Abstract excerpt
Genetic polymorphisms in the human solute carrier family 11 member 1 (SLC11A1) gene predispose to susceptibility to infectious/inflammatory diseases and cancer. Human susceptibility to these diseases exhibits allelic association with a polymorphic regulatory Z-DNA-forming microsatellite of a (GT/AC)n repeat. The carriage of different alleles may influence chromatin remodeling and accessibility by transcription...
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