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Article

Computational design of orthogonal ribosomes.

Nucleic acids research - 1 Jul 2008

Chubiz Lon M, Rao Christopher V

Abstract excerpt

Orthogonal ribosomes (o-ribosomes), also known as specialized ribosomes, are able to selectively translate mRNA not recognized by host ribosomes. As a result, they are powerful tools for investigating translational regulation and probing ribosome structure. To date, efforts directed towards engineering o-ribosomes have involved random mutagenesis-based approaches. As an alternative, we present here a...

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PMID: 18522973
DOI: 10.1093/nar/gkn354
PMCID: PMC2475622

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