Article
Mammary carcinoma behavior is programmed in the precancer stem cell.
Breast cancer research : BCR - 1 Jan 2008
Damonte Patrizia, Hodgson J Graeme, Chen Jane Qian, Young Lawrence J T, Cardiff Robert D, Borowsky Alexander D
Abstract excerpt
INTRODUCTION: The 'MINO' (mammary intraepithelial neoplasia outgrowth) mouse model of ductal carcinoma in situ (DCIS) consists of six lines with distinct morphologic phenotypes and behavior, each meeting experimentally defined criteria for 'precancer'. Specifically, these lines grow orthotopically in cleared mammary fat pads and consistently progress to an invasive phenotype that is capable of ectopic growth....
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