Article
A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor
17 May 2019
Abstract excerpt
As 3D culture has become central to investigation of tissue biology, mammary epithelial organoids have emerged as powerful tools for investigation of epithelial cell polarization and carcinogenesis. However, most current protocols start from single cells suspended in Matrigel, which can also restrict cell differentiation and behavior. Here, we show that the noncancerous mammary cell line HMT-3522 S1, when allowed...
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