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Article

Characteristics and clinical correlates of MPL 515W>L/K mutation in essential thrombocythemia.

Blood - 1 Aug 2008

Vannucchi Alessandro M, Antonioli Elisabetta, Guglielmelli Paola, Pancrazzi Alessandro, Guerini Vittoria, Barosi Giovanni, Ruggeri Marco, Specchia Giorgina, Lo-Coco Francesco, Delaini Federica, Villani Laura, Finotto Silvia, Ammatuna Emanuele, Alterini Renato, Carrai Valentina, Capaccioli Gloria, Di Lollo Simonetta, Liso Vincenzo, Rambaldi Alessandro, Bosi Alberto, Barbui Tiziano

Abstract excerpt

Among 994 patients with essential thrombocythemia (ET) who were genotyped for the MPLW515L/K mutation, 30 patients carrying the mutation were identified (3.0%), 8 of whom also displayed the JAK2V671F mutation. MPLW515L/K patients presented lower hemoglobin levels and higher platelet counts than did wild type (wt) MPL; these differences were highly significant compared with MPLwt/JAK2V617F-positive patients....

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Source

Identifiers

PMID: 18519816
DOI: 10.1182/blood-2008-01-135897

Genes

MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characteristics and clinical correlates of MPL 515W>L/K mutation in essential thrombocythemia.PMID 18519816Read ↗

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