Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin.

doi:10.1128/JVI.65.6.3284-3292.1991

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin.

Journal of virology - 1 Jun 1991

Koff A, Schwedes J F, Tegtmeyer P

Abstract excerpt

To investigate the role of the herpes simplex virus origin-binding protein (UL9) in the initiation of DNA replication, we have examined the effect of UL9 binding on the structure of the viral origin of replication. UL9 loops and alters the DNA helix of the origin regardless of the phasing of the binding sites. DNase I and micrococcal nuclease footprinting show that UL9 binds two sites in the origin and loops the...

Topics

Animals
Base Composition
Base Sequence
Binding Sites
DNA Replication
DNA, Superhelical
DNA, Viral
DNA-Binding Proteins
Deoxyribonuclease I
Models, Molecular
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Moths

Mutation

Nucleic Acid Conformation

Protein Conformation

Simplexvirus

Thermodynamics

Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1851878
DOI: 10.1128/JVI.65.6.3284-3292.1991
PMCID: PMC240986

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1851878-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin.PMID 1851878Read ↗

Association of origin binding protein and single strand DNA-binding protein, ICP8, during herpes simplex virus type 1 DNA replication in vivo.Semantic proximity Read ↗

A novel conformation of the herpes simplex virus origin of DNA replication recognized by the origin binding protein.Semantic proximity Read ↗

Two binding sites for the herpes simplex virus type 1 UL9 protein are required for efficient activity of the oriS replication origin.Semantic proximity Read ↗

DNA binding activity of the herpes simplex virus type 1 origin binding protein, UL9, can be modulated by sequences in the N terminus: correlation between transdominance and DNA binding.Semantic proximity Read ↗

Herpes simplex virus type 1 mutants for the origin-binding protein induce DNA amplification in the absence of viral replication.Semantic proximity Read ↗

A 269-amino-acid segment with a pseudo-leucine zipper and a helix-turn-helix motif codes for the sequence-specific DNA-binding domain of herpes simplex virus type 1 origin-binding protein.Semantic proximity Read ↗

Inhibition of herpes simplex virus type 1 DNA replication by mutant forms of the origin-binding protein.Semantic proximity Read ↗

Unwinding of a herpes simplex virus type 1 origin of replication (Ori(S)) by a complex of the viral origin binding protein and the single-stranded DNA binding protein.Semantic proximity Read ↗

Genome replication and progeny virion production of herpes simplex virus type 1 mutants with temperature-sensitive lesions in the origin-binding protein.Semantic proximity Read ↗

Conserved Residues in the UL24 Protein of Herpes Simplex Virus 1 Are Important for Dispersal of the Nucleolar Protein NucleolinSemantic proximity Read ↗

Herpes simplex virus type 1 origin-specific binding protein: oriS-binding properties and effects of cellular proteins.Semantic proximity Read ↗

The Exonuclease Activity of Herpes Simplex Virus 1 UL12 Is Required for Production of Viral DNA That Can Be Packaged To Produce Infectious Virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.