Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Herpes simplex virus type 1 origin-specific binding protein: oriS-binding properties and effects of cellular proteins.

Journal of virology - 1 Jun 1991

Dabrowski C E, Schaffer P A

Abstract excerpt

The herpes simplex virus type 1 (HSV-1) origin of replication, oriS, contains three highly homologous sequences, sites I, II, and III. The HSV-1 origin-binding protein (OBP), the product of the UL9 gene, has been shown to bind specifically to sites I and II. In this study, gel shift analysis was used to characterize interactions between site I DNA and proteins in infected and uninfected cell extracts. The...

Topics

Animals
Base Sequence
Binding Sites
Cells, Cultured
DNA, Viral
DNA-Binding Proteins
Genes, Viral
Herpes Simplex
Molecular Sequence Data
Mutation
Recombinant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Simplexvirus

Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1851874
DOI: 10.1128/JVI.65.6.3140-3150.1991
PMCID: PMC240970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1851874-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Herpes simplex virus type 1 origin-specific binding protein: oriS-binding properties and effects of cellular proteins.PMID 1851874Read ↗

Two binding sites for the herpes simplex virus type 1 UL9 protein are required for efficient activity of the oriS replication origin.Semantic proximity Read ↗

A 269-amino-acid segment with a pseudo-leucine zipper and a helix-turn-helix motif codes for the sequence-specific DNA-binding domain of herpes simplex virus type 1 origin-binding protein.Semantic proximity Read ↗

A novel conformation of the herpes simplex virus origin of DNA replication recognized by the origin binding protein.Semantic proximity Read ↗

Characterization of the herpes simplex virus origin binding protein interaction with OriS.Semantic proximity Read ↗

Physical interaction between the herpes simplex virus 1 origin-binding protein and single-stranded DNA-binding protein ICP8.Semantic proximity Read ↗

Association of origin binding protein and single strand DNA-binding protein, ICP8, during herpes simplex virus type 1 DNA replication in vivo.Semantic proximity Read ↗

Inhibition of herpes simplex virus type 1 DNA replication by mutant forms of the origin-binding protein.Semantic proximity Read ↗

Elements in the transcriptional regulatory region flanking herpes simplex virus type 1 oriS stimulate origin function.Semantic proximity Read ↗

Unwinding of a herpes simplex virus type 1 origin of replication (Ori(S)) by a complex of the viral origin binding protein and the single-stranded DNA binding protein.Semantic proximity Read ↗

Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin.Semantic proximity Read ↗

DNA binding activity of the herpes simplex virus type 1 origin binding protein, UL9, can be modulated by sequences in the N terminus: correlation between transdominance and DNA binding.Semantic proximity Read ↗

Replication from <i>oriP</i> of Epstein-Barr Virus Requires Exact Spacing of Two Bound Dimers of EBNA1 Which Bend DNASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.