Herpes simplex virus type 1 mutants for the origin-binding protein induce DNA amplification in the absence of viral replication.

doi:10.1016/0042-6822(90)90319-m

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Article

Herpes simplex virus type 1 mutants for the origin-binding protein induce DNA amplification in the absence of viral replication.

Virology - 1 Nov 1990

Heilbronn R, Weller S K, zur Hausen H

Abstract excerpt

Herpes simplex virus (HSV) induces DNA amplification within the host cell genome, which is mediated by a set of six of seven HSV replication genes. The origin-binding protein (UL9) is dispensible. By the use of HSV mutants for the UL9 gene we show here that HSV can induce DNA amplification in the...

Topics

Animals
Cell Line
Cell Transformation, Viral
DNA-Binding Proteins
Gene Amplification
Genes, Viral
Mutation
Restriction Mapping
Simian virus 40
Simplexvirus
Viral Proteins

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