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Article

Herpes simplex virus type 1 mutants for the origin-binding protein induce DNA amplification in the absence of viral replication.

Virology - 1 Nov 1990

Heilbronn R, Weller S K, zur Hausen H

Abstract excerpt

Herpes simplex virus (HSV) induces DNA amplification within the host cell genome, which is mediated by a set of six of seven HSV replication genes. The origin-binding protein (UL9) is dispensible. By the use of HSV mutants for the UL9 gene we show here that HSV can induce DNA amplification in the absence of lytic viral growth in contrast to replication-negative mutants for either the UL8 or UL52 gene used as...

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Source

Identifiers

PMID: 2171219
DOI: 10.1016/0042-6822(90)90319-m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Herpes simplex virus type 1 mutants for the origin-binding protein induce DNA amplification in the absence of viral replication.PMID 2171219Read ↗

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Genome replication and progeny virion production of herpes simplex virus type 1 mutants with temperature-sensitive lesions in the origin-binding protein.Semantic proximity Read ↗

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Association of origin binding protein and single strand DNA-binding protein, ICP8, during herpes simplex virus type 1 DNA replication in vivo.Semantic proximity Read ↗

Evaluation of the lytic origins of replication of Kaposi's sarcoma-associated virus/human herpesvirus 8 in the context of the viral genome.Semantic proximity Read ↗

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