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Article

A novel conformation of the herpes simplex virus origin of DNA replication recognized by the origin binding protein.

The Journal of biological chemistry - 25 Feb 2000

Aslani A, Simonsson S, Elias P

Abstract excerpt

The Herpes simplex virus type I origin binding protein (OBP) is a sequence-specific DNA-binding protein and a dimeric DNA helicase encoded by the UL9 gene. It is required for the activation of the viral origin of DNA replication oriS. Here we demonstrate that the linear double-stranded form of oriS can be converted by heat treatment to a stable novel conformation referred to as oriS*. Studies using S1 nuclease...

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Source

Identifiers

PMID: 10681580
DOI: 10.1074/jbc.275.8.5880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel conformation of the herpes simplex virus origin of DNA replication recognized by the origin binding protein.PMID 10681580Read ↗

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