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Article

Two binding sites for the herpes simplex virus type 1 UL9 protein are required for efficient activity of the oriS replication origin.

The Journal of general virology - 1 Jun 1990

Weir H M, Stow N D

Abstract excerpt

Two sites within the short region origin of DNA replication (oriS) in herpes simplex virus type 1 (HSV-1) which bind the product of the UL9 gene have previously been identified. One of these sites (site I) contains an 11 bp sequence which is also present in oriS of varicella-zoster virus, and the other (site II) includes a related element differing in two positions. A third sequence (motif III), which lies close...

Topics

Base Sequence
Binding Sites
DNA Replication
DNA, Viral
DNA-Binding Proteins
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Simplexvirus
Viral Proteins
Virus Replication

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Identifiers

PMID: 2161905
DOI: 10.1099/0022-1317-71-6-1379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2161905-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Two binding sites for the herpes simplex virus type 1 UL9 protein are required for efficient activity of the oriS replication origin.PMID 2161905Read ↗

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A novel conformation of the herpes simplex virus origin of DNA replication recognized by the origin binding protein.Semantic proximity Read ↗

A 269-amino-acid segment with a pseudo-leucine zipper and a helix-turn-helix motif codes for the sequence-specific DNA-binding domain of herpes simplex virus type 1 origin-binding protein.Semantic proximity Read ↗

Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin.Semantic proximity Read ↗

Characterization of the herpes simplex virus origin binding protein interaction with OriS.Semantic proximity Read ↗

Association of origin binding protein and single strand DNA-binding protein, ICP8, during herpes simplex virus type 1 DNA replication in vivo.Semantic proximity Read ↗

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Unwinding of a herpes simplex virus type 1 origin of replication (Ori(S)) by a complex of the viral origin binding protein and the single-stranded DNA binding protein.Semantic proximity Read ↗

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Elements in the transcriptional regulatory region flanking herpes simplex virus type 1 oriS stimulate origin function.Semantic proximity Read ↗

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