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Article

Characterization of the herpes simplex virus origin binding protein interaction with OriS.

The Journal of biological chemistry - 25 Dec 1991

Hazuda D J, Perry H C, Naylor A M, McClements W L

Abstract excerpt

The origin binding protein (OBP) of herpes simplex virus (HSV), which is essential for viral DNA replication, binds specifically to sequences within the viral replication origin(s) (for a review, see Challberg, M.D., and Kelly, T. J. (1989) Annu. Rev. Biochem. 58, 671-717). Using either a COOH-terminal OBP protein A fusion or the full-length protein, each expressed in Escherichia coli, we investigated the...

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Source

Identifiers

PMID: 1662213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Characterization of the herpes simplex virus origin binding protein interaction with OriS.PMID 1662213Read ↗

A novel conformation of the herpes simplex virus origin of DNA replication recognized by the origin binding protein.Semantic proximity Read ↗

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Herpes simplex virus type 1 origin-specific binding protein: oriS-binding properties and effects of cellular proteins.Semantic proximity Read ↗

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Two binding sites for the herpes simplex virus type 1 UL9 protein are required for efficient activity of the oriS replication origin.Semantic proximity Read ↗

Association of origin binding protein and single strand DNA-binding protein, ICP8, during herpes simplex virus type 1 DNA replication in vivo.Semantic proximity Read ↗

Genome replication and progeny virion production of herpes simplex virus type 1 mutants with temperature-sensitive lesions in the origin-binding protein.Semantic proximity Read ↗

Physical interaction between the herpes simplex virus 1 origin-binding protein and single-stranded DNA-binding protein ICP8.Semantic proximity Read ↗

Sequence requirements for interaction of human herpesvirus 7 origin binding protein with the origin of lytic replication.Semantic proximity Read ↗

Unwinding of a herpes simplex virus type 1 origin of replication (Ori(S)) by a complex of the viral origin binding protein and the single-stranded DNA binding protein.Semantic proximity Read ↗

Herpes simplex virus type 1 C-terminal variants of the origin binding protein (OBP), OBPC-1 and OBPC-2, cooperatively regulate viral DNA levels in vitro, and OBPC-2 affects mortality in mice.Semantic proximity Read ↗

Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin.Semantic proximity Read ↗

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