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Article

Characterization of the herpes simplex virus origin binding protein interaction with OriS.

The Journal of biological chemistry - 25 Dec 1991

Hazuda D J, Perry H C, Naylor A M, McClements W L

Abstract excerpt

The origin binding protein (OBP) of herpes simplex virus (HSV), which is essential for viral DNA replication, binds specifically to sequences within the viral replication origin(s) (for a review, see Challberg, M.D., and Kelly, T. J. (1989) Annu. Rev. Biochem. 58, 671-717). Using either a COOH-terminal OBP protein A fusion or the full-length protein, each expressed in Escherichia coli, we investigated the...

Topics

Base Sequence
Binding, Competitive
Cloning, Molecular
DNA Replication
DNA, Viral
DNA-Binding Proteins
Molecular Sequence Data
Mutation
Nucleic Acid Heteroduplexes
Oligonucleotides
Recombinant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Simplexvirus

Viral Proteins

Source

Identifiers

PMID: 1662213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1662213-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Characterization of the herpes simplex virus origin binding protein interaction with OriS.PMID 1662213Read ↗

A novel conformation of the herpes simplex virus origin of DNA replication recognized by the origin binding protein.Semantic proximity Read ↗

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Unwinding of a herpes simplex virus type 1 origin of replication (Ori(S)) by a complex of the viral origin binding protein and the single-stranded DNA binding protein.Semantic proximity Read ↗

Herpes simplex virus type 1 C-terminal variants of the origin binding protein (OBP), OBPC-1 and OBPC-2, cooperatively regulate viral DNA levels in vitro, and OBPC-2 affects mortality in mice.Semantic proximity Read ↗

Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin.Semantic proximity Read ↗

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