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Article

The open reading frames UL3, UL4, UL10, and UL16 are dispensable for the replication of herpes simplex virus 1 in cell culture.

Journal of virology - 1 Feb 1991

Baines J D, Roizman B

Abstract excerpt

By means of insertion and deletion mutagenesis, we have constructed four herpes simplex virus 1 recombinants, each lacking most sequences encoding a different open reading frame. The deleted genes are located in the unique sequences of the long component and include those designated UL3, UL4, UL10, and UL16. The recombinant virus R7211 lacks 579 of the 696 bp of UL3. The recombinant virus R7217 lacks 307 of the...

Topics

Animals
Cells, Cultured
Chromosome Deletion
DNA, Viral
Genes, Viral
Kinetics
Open Reading Frames
Phenotype
Plasmids
Rabbits
Recombination, Genetic
Restriction Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Simplexvirus

Skin

Vero Cells

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1846207
DOI: 10.1128/JVI.65.2.938-944.1991
PMCID: PMC239835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1846207-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The open reading frames UL3, UL4, UL10, and UL16 are dispensable for the replication of herpes simplex virus 1 in cell culture.PMID 1846207Read ↗

Characterization of a herpes simplex virus type 1 deletion variant (1703) which under-produces Vmw63 during immediate early conditions of infection.Semantic proximity Read ↗

Identification of three genes nonessential for growth in cell culture near the right terminus of the unique sequences of long component of herpes simplex virus 1.Semantic proximity Read ↗

Comparative Analysis of UL16 Mutants Derived from Multiple Strains of Herpes Simplex Virus 2 (HSV-2) and HSV-1 Reveals Species-Specific Requirements for the UL16 Protein.Semantic proximity Read ↗

The myristylated virion proteins of herpes simplex virus type 1: investigation of their role in the virus life cycle.Semantic proximity Read ↗

Genomic deletions and mutations resulting in the loss of eight genes reduce the in vivo replication capacity of Meleagrid herpesvirus 1.Semantic proximity Read ↗

A cosmid-based system for constructing mutants of herpes simplex virus type 1.Semantic proximity Read ↗

The product of the UL12.5 gene of herpes simplex virus type 1 is not essential for lytic viral growth and is not specifically associated with capsids.Semantic proximity Read ↗

Comparative Analysis of <i>UL16</i> Mutants Derived from Multiple Strains of HSV-2 and HSV-1 Reveals Species-Specific Requirements for the UL16 ProteinSemantic proximity Read ↗

A Mutation in the UL24 Gene Abolishes Expression of the Newly Identified UL24.5 Protein of Herpes Simplex Virus 1 and Leads to an Increase in Pathogenicity in Mice.Semantic proximity Read ↗

Identification of multiple sites suitable for insertion of foreign genes in herpes simplex virus genomesSemantic proximity Read ↗

Characterization of ICP6::lacZ insertion mutants of the UL15 gene of herpes simplex virus type 1 reveals the translation of two proteins.Semantic proximity Read ↗

Genetic analysis of the role of herpes simplex virus type 1 glycoprotein K in infectious virus production and egress.Semantic proximity Read ↗

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