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Article

Inhibition of herpes simplex virus type 1 DNA replication by mutant forms of the origin-binding protein.

Virology - 1 Oct 1993

Stow N D, Hammarsten O, Arbuckle M I, Elias P

Abstract excerpt

The herpes simplex virus type 1 (HSV-1) origin-binding protein (OBP) is a sequence-specific DNA binding protein encoded by gene UL9 which interacts with the viral origins of DNA replication and also exhibits DNA helicase activity. Sequence-specific DNA binding activity has previously been shown to reside within the C-terminal 317 amino acids, and when expressed alone, this domain exerts a dominant inhibitory...

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Identifiers

PMID: 8396795
DOI: 10.1006/viro.1993.1496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of herpes simplex virus type 1 DNA replication by mutant forms of the origin-binding protein.PMID 8396795Read ↗

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Genome replication and progeny virion production of herpes simplex virus type 1 mutants with temperature-sensitive lesions in the origin-binding protein.Semantic proximity Read ↗

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Characterization of the herpes simplex virus origin binding protein interaction with OriS.Semantic proximity Read ↗

DNA binding activity of the herpes simplex virus type 1 origin binding protein, UL9, can be modulated by sequences in the N terminus: correlation between transdominance and DNA binding.Semantic proximity Read ↗

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Herpes simplex virus type 1 C-terminal variants of the origin binding protein (OBP), OBPC-1 and OBPC-2, cooperatively regulate viral DNA levels in vitro, and OBPC-2 affects mortality in mice.Semantic proximity Read ↗

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A novel conformation of the herpes simplex virus origin of DNA replication recognized by the origin binding protein.Semantic proximity Read ↗

Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin.Semantic proximity Read ↗

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