Article
Association of polymorphisms of toll-like receptor 4 with a reduced prevalence of hay fever and atopy.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology - 1 May 2008
Senthilselvan Ambikaipakan, Rennie Donna, Chénard Liliane, Burch Lauranell H, Babiuk Lorne, Schwartz David A, Dosman James A
Abstract excerpt
BACKGROUND: The response to innate immune stimuli seems to be critical to conditioning adaptive immunity. Early exposure to endotoxin initiates immune responses that have been shown to alter the risk of asthma and allergic diseases. The toll-like receptor 4 (TLR4) gene encodes the principal innate immunity receptor in humans for bacterial endotoxin. Polymorphisms in the TLR4 gene may regulate the effects of...
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