Article
Transcriptional interference between the EBV transcription factors EB1 and R: both DNA-binding and activation domains of EB1 are required.
Nucleic acids research - 25 Mar 1991
Giot J F, Mikaelian I, Buisson M, Manet E, Joab I, Nicolas J C, Sergeant A
Abstract excerpt
The switch from latency to a productive infection in EBV-infected B cells is linked to the expression of two viral sequence-specific DNA-binding transcription factors called EB1 and R. EB1 shares sequence homologies with the bZIP family of proteins in the basic region required for specific DNA interaction. Here, we provide evidence that EB1 and R can synergistically activate specific transcription, and that...
Topics
- Amino Acid Sequence
- Base Sequence
- Blotting, Western
- DNA, Viral
- DNA-Binding Proteins
- Genes, Viral
- HeLa Cells
- Herpesvirus 4, Human
- Humans
- Molecular Sequence Data
- Mutation