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Article

Regulation of yeast actin behavior by interaction of charged residues across the interdomain cleft.

The Journal of biological chemistry - 21 Jun 2002

Yao Xiaoyi, Nguyen Vinh, Wriggers Willy, Rubenstein Peter A

Abstract excerpt

His(73) participates in the regulation of the nucleotide binding cleft conformation in yeast actin. Earlier molecular dynamics studies suggested that Asp(184) interacts with His(73) thereby stabilizing a "closed-cleft" G-actin. However, beta-actin in the open-cleft state shows a closer interaction of His(73) with Asp(179) than with Asp(184). We have thus assessed the relative importance of Asp(184) and Asp(179)...

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PMID: 11940592
DOI: 10.1074/jbc.M201685200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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