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The genetic architecture of schizophrenia: new mutations and emerging paradigms.

Annual review of medicine - 1 Jan 2012

Rodriguez-Murillo Laura, Gogos Joseph A, Karayiorgou Maria

Abstract excerpt

Although a genetic component of schizophrenia has been acknowledged for a long time, the underlying architecture of the genetic risk remains a contentious issue. Early linkage and candidate association studies led to largely inconclusive results. More recently, the availability of powerful technologies, samples of sufficient sizes, and genome-wide panels of genetic markers facilitated systematic and agnostic...

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PMID: 22034867
DOI: 10.1146/annurev-med-072010-091100

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